Laboratory of Molecular Chronobiology

Nicolas Cermakian


Publications: Research articles (with original data)

  • Cuesta, M., Boudreau, P., Dubeau-Laramée, G., Cermakian, N.#, Boivin, D.B.# (2016) Simulated night shift disrupts circadian rhythms of immune functions in humans. Journal of Immunology, 196(6):2466-75.  # Co-corresponding authors
  • Freyburger, M., Pierre, A., Paquette, G., Bélanger-Nelson, E., Bedont, J., Gaudreault, P.O., Drolet, G., Laforest, S., Blackshaw, S., Cermakian, N., Doucet, G., Mongrain, V. (2016) EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep, 39(3):613-24.
  • Landgraf, D., Joiner, W.J., McCarthy, M.J., Kiessling, S., Barandas, R., Young, J.W., Cermakian, N., Welsh, D.K. (2016) The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology, 107:262-270.
  • Bhardwaj, S.K., Stojkovic, K., Kiessling, S., Srivastava, L.K., Cermakian, N. (2015) Constant light uncovers behavioral effects of a mutation in the schizophrenia risk gene Dtnbp1 in mice. Behavioural Brain Research, 284:58-68.
  • Cuesta, M., Cermakian, N., Boivin, D.B. (2015) Glucocorticoids entrain molecular clock components in human peripheral cells. FASEB Journal, 29(4):1360-70.
  • Reynolds, L.M., Makowski, C.S., Yogendran, S.V., Kiessling, S., Cermakian, N., Flores, C. (2015) Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner. Neuropsychopharmacology, 40:1101-12.
  • Yang, Y., Duguay, D., Fahrenkrug, J., Cermakian, N., Wing, S.S. (2014) USP2 regulates the intracellular localization of PER1 and circadian gene expression. Journal of Biological Rhythms, 29(4):243-256.
  • Westfall, S., Aguilar-Valles, A., Mongrain, V., Luheshi, G.N., Cermakian, N. (2013) Time-dependent effects of localized inflammation on peripheral clock gene expression in rats. PLoS ONE, 8(3): e59808.
  • Yang, Y., Duguay, D., Bédard, N., Rachalski, A., Baquiran, G., Na, C.H., Fahrenkrug, J., Storch, K.F., Peng, J., Wing, S.S., Cermakian, N. (2012) Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2. Biology Open, 1:789-801.
  • Fortier, E.E., Rooney, J., Dardente, H., Hardy, M.P., Labrecque, N., Cermakian, N. (2011) Circadian variation of the response of T cells to antigen. Journal of Immunology, 187(12):6291-300.
  • Duguay, D., Bélanger-Nelson, E., Mongrain, V., Beben, A., Khatchadourian, A., Cermakian, N. (2011) Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS ONE, 6(10): e26430.
  • Dufour, C.R., Pham, N.H.H., Levasseur, M.P., Eichner, L.J., Wilson, B.J., Duguay, D., Poirier-Héon, J.F., Cermakian, N., Giguère, V. (2011) Genomic convergence between ERR, PROX1 and BMAL1 in circadian control of metabolism. PLoS Genetics, 7(6):e1002143.
  • Cermakian, N., Waddington Lamont, E., Boudreau, P., Boivin, D.B. (2011) Circadian clock gene expression in brain regions of Alzheimer's disease patients and control subjects. Journal of Biological Rhythms, 26(2):160-170.
  • Rousseau, J., Klinger, S., Rachalski, A., Turgeon, B., Déléris, P., Vigneault, E., Poirier-Héon, J.F., Davoli, M.A., Mechawar, N., El Mestikawy, S., Cermakian, N., Meloche, S. (2010) Targeted Inactivation of Mapk4 in Mice Reveals Specific Non-Redundant Functions of Erk3/Erk4 Subfamily MAP Kinases. Mol Cell Biol, 30(24):5752-63.
  • Labialle, S., Croteau, S., Bélanger, V., McMurray, E.N., Ruan, X.,, Moussette, S., Jonnaert, M., Schmidt, J.V., Cermakian, N., Naumova, A.K. (2008) Novel imprinted transcripts from the Dlk1-Gtl2 intergenic region, Mico1 and Mico1os, show circadian oscillations. Epigenetics, 3(6):322-9.
  • Mongrain, V., Ruan, X., Dardente, H., Fortier, E.E., Cermakian, N. (2008) Clock-dependent and independent transcriptional control of the two isoforms from the mouse Ror gene. Genes to Cells, 13(12):1197-1210.
  • Labialle, S., Yang, L., Ruan, X., Villemain, A., Schmidt, J.V., Hernandez, A., Wiltshire, T., Cermakian, N., Naumova, A.K. (2008) Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Human Molecular Genetics, 17(1):15-26.
  • James, F.O., Boivin, D.B., Charbonneau, S., Bélanger, V., Cermakian, N. (2007) Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles. Chronobiology International, 24(6):1009-1034.
  • James, F.O., Cermakian, N., Boivin, D.B. (2007) Circadian rhythms of melatonin, cortisol and clock gene expression to during simulated night shift work. Sleep, 30(11):1427-1436.
  • Dardente, H., Fortier, E.E., Martineau, V., Cermakian, N. (2007) CRYPTOCHROMES impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression. Biochemical Journal, 402(3):525-536.
  • Doi, M., Cho, S., Yujnovsky, I., Hirayama, J., Cermakian, N., Cato, A.C.B., Sassone-Corsi, P. (2007) Light-inducible and clock-controlled expression of MAP Kinase Phosphatase 1 in the mouse central pacemaker neurons. Journal of Biological Rhythms, 22(2):127-139.
  • Bélanger, V., Picard, N., Cermakian, N. (2006) The circadian regulation of Presenilin-2 gene expression. Chronobiology International, 23(4):747-766.
  • Guillaumond, F., Dardente, H., Giguère, V., Cermakian, N. (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. Journal of Biological Rhythms, 20(5):391-403.
  • Granda, T., Liu, X.H., Cermakian, N., Smaaland, R., Filipski, E., Sassone-Corsi, P., Lévi, F. (2004) Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumour. FASEB Journal 19(2):304-306.
  • Morse, D.*, Cermakian, N.*, Brancorsini, S., Parvinen, M., Sassone-Corsi, P. (2003) No circadian rhythm in testis: Period1 expression is Clock independent and developmentally regulated in the mouse. Molecular Endocrinology 17(1):141-151.
  • Pando, M.P., Morse, D., Cermakian, N., Sassone-Corsi, P. (2002) Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell 110(1):107-117.
  • Travnickova-Bendova, Z., Cermakian, N., Reppert, S.M., Sassone-Corsi, P. (2002) Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK:BMAL1 activity. Proc Natl Acad Sci USA 99(11):7728-7733.
  • Cermakian, N.*, Pando, M.P.*, Thompson, C.L.*, Pinchak, A.B., Selby, C.P., Gutierrez, L., Wells, D.E., Cahill, G.M., Sancar, A., Sassone-Corsi, P. (2002) Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Current Biology 12(10):844-848.
  • Cermakian, N., Monaco, L., Pando, M.P., Dierich, A., Sassone-Corsi, P. (2001) Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene. The EMBO Journal 20:3967-3974.
  • Pando, M.P., Pinchak, A.B., Cermakian, N., Sassone-Corsi, P. (2001) A cell based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock. Proc Natl Acad Sci USA 98(18):10178-10183.
  • Li, J., Maga, J.A., Cermakian, N., Cedergren, R., Feagin, J.E. (2001) Identification and characterization of a Plasmodium falciparum RNA polymerase gene with similarity to mitochondrial RNA polymerases. Molecular and Biochemical Parasitology 113:261-269.
  • Crosio, C.*, Cermakian, N.*, Allis, C.D., Sassone-Corsi, P. (2000) Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neuroscience 3(12): 1241-1247.
  • Cermakian, N., Whitmore, D., Foulkes, N.S., Sassone-Corsi, P. (2000) Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Proc Natl Acad Sci USA 97(8):4339-4344.
  • Cermakian, N., McClain, W.H., Cedergren, R. (1998) tRNA nucleotide 47: an evolutionary enigma. RNA 4(8):928-936.
  • Bourdeau, V., Steinberg, S.V., Ferbeyre, G., Emond, R., Cermakian, N., Cedergren, R. (1998) Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs. Proc Natl Acad Sci USA 95(4):1375-1380.
  • Cermakian, N.*, Ikeda, T.M.*, Miramontes, P., Lang, B.F., Gray, M.W., Cedergren, R. (1997) On the evolution of the single-subunit RNA polymerases. Journal of Molecular Evolution 45(6):671-681.
  • Cermakian, N., Ikeda, T.M., Cedergren, R., Gray, M.W. (1996) Sequences homologous to yeast mitochondrial and bacteriophage T3 and T7 RNA polymerase genes are widespread throughout the eukaryotic lineage. Nucleic Acid Research 24(4):648-654.

* Co-first authors

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